Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
|Published (Last):||12 October 2010|
|PDF File Size:||13.8 Mb|
|ePub File Size:||16.51 Mb|
|Price:||Free* [*Free Regsitration Required]|
The in vitro drug release profiles of the matrices are evaluated, and its release mechanism was studied.
A spherical morphology of the prepared nanoparticles was observed in the SEM images Figure 8. An angle of repose of less than 30 degrees indicates good flow properties. Rso in vitro drug release studies were carried out using dialysis bag method [ 25 ]. Sink condition was maintained for the whole experiment.
Table 3 gives the physical parameters such as hardness, thickness, friability and weight uniformity of all the fabricated tablets. This may also be the auxiliary reason for obtaining slow drug release profiles through GC and GD matrix rslo. All the tablets were stored in eudraglt containers for further study. Subscribe to Premium Services Searches: Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to favor less penetration of the dissolution medium in the tablets.
Weight variation test was performed according to the official method [ 20 ]. Eudragit RSPO contains quaternary ammonium groups, and solubilization of these quaternary ammonium groups in acidic pH leads to formation of pores in the matrix, thereby releasing metformin HCl in the acidic pH. These results eudrahit in good agreement with the results reported by Gannu et al.
An obstacle to more successful use of metformin therapy is the high incidence of concomitant gastrointestinal symptoms, such as abdominal discomfort, nausea, and diarrhea that especially occurs during the initial period of treatment. It is a solid substance in form of white powder with a faint amine-like odour. Unlike other antidiabetic drugs metformin HCl does not induce hypoglycemia at any reasonable dose, and hence it is called as an antihyperglycaemic rather than a hypoglycemic drug [ 2 ].
Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The optimized formulation was characterized for in vitro drug release and structural characterization. Compared to other methods like emulsion [ 19 ], desolvation [ 20 ], salting out, and supercritical fluid technology it involves an economy of energy and steps and does not require specialized equipment.
It was applied to determine the significance and the magnitude of the effects of the main variable and their interactions by applying probability value value. Normally the ratio greater than 4 is desirable for the model to be used effectively [ 28 ]. The percent drug release was determined by. The interactions between ratio of a polymer to a drug and concentration of a surfactant and ratio of a polymer to a drug and sonication time were also statistically significant on EE.
Journal of Nanomaterials
Or if you don’t have an account with us yet, then click here to register. Mumbai, Indiaand gum copal and gum damar were received as a gift sample from Imex Inc. Each sample was measured in triplicate.
A graphical representation of an optimized mean particle size is given in Figure 6: Drops of nanoparticles dispersion were applied on the stub and dried overnight. Where R and UR are the released and unreleased percentages, respectively, at time t ; k 1k 2k 3k 4and k 5 are the rate constants of zero-order, first-order, Higuchi matrix, Peppas-Korsmeyer, and Hixon-Crowell model, respectively.
Click here to view all the property values for this datasheet as they were originally entered into MatWeb. Matrix systems are widely used in oral controlled drug delivery because of their flexibility, cost effectiveness, low influence of the physiological variables on its release behavior and broad regulatory acceptance [ 67 ].
The aim of the optimization was to obtain small particles size, small PDI, high EE, and high zeta potential. Other Engineering Material Material Notes: In each formulation, the amount of the active ingredient is mg and the total weight of a tablet is mg. The hydrophilic polymer selected for the present study was Eudragit RSPO, which provide pH-independent drug release to oral dosage forms that can be used for formulating the sustained-release dosage forms [ 14 ].
The effect of amount of polymer, surfactant concentration, and sonication time on particle size, particle distribution, encapsulation efficiency EEand zeta potential were assessed and optimized utilizing a three-factor, three-level Box-Behnken Design BBD of experiment.
Evonik EUDRAGIT® RS PO Copolymer
The release profiles for both pH 7. College of Pharmacy, Kamptee, Nagpur, Rsspo for providing necessary facilities to carry out this work. This indicates that the drug is compatible with the polymers used in the investigation.
Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults. In order to compare the release profile of different formulas with possible difference in release mechanisms n valuesa mean dissolution time MDT [ 14 ] was calculated using Eq. MatWeb is intended for personal, non-commercial use. It was also found that SDS was able to increase the drug solubility by threefold when compared to the solubility of tenofovir in water.
Subscribe to Table of Contents Alerts.